Endocrine Abstracts

Introduction: The standard management of Graves’ disease includes initial use of antithyroid drugs, while radioactive iodine ablation or thyroid surgery are later definitive treatment options. Management of thyrotoxicosis secondary to the use of amiodarone can be challenging as patients may not promptly respond to antithyroid or corticosteroid therapy, and thyrotoxicosis may be more harmful in those patients owing to the underlying cardiac disease. In rare thyrotoxicosis ...

Introduction: Multiple adverse health outcomes are reported in response to low vitamin D and/or hyperparathyroidism.Aim and methods: A cross-sectional study in a random sample of mainly non-vitamin D supplemented Danish women (N=1580) during winter-time. We investigated prevalence of vitamin D insufficiency, hyperparathyroidism, general health and quality of life (QoL) as assessed by a general health questionnaire and a validated hyperparathyroi...

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

Abstract: A 55-year-old woman was admitted to our hospital due to severe hyperthyreosis. She started to feel symptoms of hyper-metabolism four months prior to hospitalization. At that time she was admitted in regional hospital and had gastroenterological examination because of diarrhea. Crohn’s disease was diagnosed and therapy started. At the same time, thyrosupressive therapy started. She had a history of hyperthyreosis thirteen years ago, duodenal hemorrhage ulcer, hyp...

Background: Thyroid cancer is the most frequent endocrine malignancy, with >7000 cases diagnosed in central Europe every year. Recently, ALK/EML4 translocations have been reported in single cases in anaplastic thyroid cancer (ATC). Little is known about the frequency of ALK alterations in poorly differentiated thyroid cancer (PTC). Our aim was to investigate the frequency of ALK alterations in patients with advanced thyroid carcinomas.Material and me...

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

Introduction: Neurogenic hypertension is associated with unilateral neurovascular compression of the brainstem and cranial nerves V, IX-X, VII, VIII. Causes may include nerve injury, vascular compression, tumors. Symptomatology seems hyperactive dysfunction syndrome of the cranial nerves. In the clinical picture, it can be seen trigeminal neuralgia, vertigo, tinnitus, hemifacial spasm, and in some cases hypertension.Case report: Female patient, 45 years ...

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...